Sunday, May 24, 2009

Eicosanoids and Ischemic Heart Disease

Dr. William Lands, one of the pioneers of the eicosanoid field, compiled this graph. It may be the single most important clue we have about the relationship between diet and ischemic heart disease (heart attacks).

To explain it fully, we have to take a few steps back. Dietary polyunsaturated fatty acids (PUFA) are primarily omega-6 and omega-3. This is a chemical designation that refers to the position of a double bond along the fatty acid's carbon chain. Omega-6 fats are found abundantly in industrial vegetable oils (corn, soybean, sunflower, cottonseed, etc.) and certain nuts, and in lesser amounts in meats, dairy and grains. Omega-3 fats are found abundantly in seafood and a few seeds such as flax and walnuts, and in smaller amounts in meats, green vegetables and dairy.

The body uses a multi-step process to convert omega-3 and omega-6 fats into eicosanoids, which are a diverse and potent class of signaling molecules. The first step is to convert PUFA into highly unsaturated fatty acids, or HUFA. These include arachidonic acid (AA), an omega-6 HUFA, eicosapentaenoic acid (EPA), an omega-3 HUFA, and several others in the 20- to 22-carbon length range.

HUFA are stored in cell membranes and they are the direct precursors of eicosanoids. When the cell needs eicosanoids, it liberates HUFA from the membrane and converts it. The proportion of omega-6 to omega-3 HUFA in the membrane is proportional to the long-term proportion of omega-6 and omega-3 in the diet. Enzymes do not discriminate between omega-6 and omega-3 HUFA when they create eicosanoids. Therefore, the proportion of omega-6- to omega-3-derived eicosanoids is proportional to dietary intake.

Omega-6 eicosanoids are potently inflammatory and thrombotic (promote blood clotting, such as thromboxane A2), while omega-3 eicosanoids are less inflammatory, less thrombotic and participate in long-term repair processes.

Many of the studies that have looked at the relationship between HUFA and heart attacks used blood plasma (serum lipids). Dr. Lands has pointed out that plasma HUFA do not accurately reflect dietary omega-6/3 balance, and they don't correlate well with heart attack risk. What does correlate strikingly well with both dietary intake and heart attack risk is the proportion of omega-6 HUFA in tissue, which reflects the amount contained in cell membranes. That's what we're looking at in the graph above: the proportion of omega-6 HUFA in the total tissue HUFA pool, vs. coronary heart disease death rate.

You can see that the correlation is striking, both between populations and within them. Greenland Inuit have the lowest proportion of omega-6 HUFA, due to a low intake of omega-6 and an exceptionally high intake of seafood. They also have an extraordinarily low risk of heart attack death. The red dots are from the Multiple Risk Factor Intervention Trial (MRFIT), which I'll be covering in a bit more detail in a later post. They're important because they confirm that the trend holds true within a population, and not just between populations.

In the next post, I'll be delving into this concept in more detail, and explaining why it's not just the ratio that matters, but also the total intake of omega-6. I'll also be providing more evidence to support the theory.

17 comments:

  1. As a sign of gratitude for how my wife was saved from Ischemic Heart Disease, i decided to reach out to those still suffering from this.
    My wife suffered Ischemic Heart Disease in the year 2013 and it was really tough and heartbreaking for me because she was my all and the symptoms were terrible, she always complain of shortness of breath, and she always have swelling in her abdomen . we tried various therapies prescribed by our neurologist but none could cure her. I searched for a cure and i saw a testimony by someone who was cured and so many other with similar body problem, and he left the contact of the doctor who had the cure to Ischemic Heart Disease . I never imagined Ischemic Heart Disease. has a natural cure not until i contacted him and he assured me my wife will be fine. I got the herbal medication he recommended and my wife used it and in one months time she was fully okay even up till this moment she is so full of life.Ischemic Heart Disease . has a cure and it is a herbal cure contact the doctor for more info on drwilliams098675@gmail.com on how to get the medication. Thanks admin for such an informative blog.

    ReplyDelete
  2. There are some natural remedies that can be used in the prevention and eliminate diabetes totally. However, the single most important aspect of a diabetes control plan is adopting a wholesome life style Inner Peace, Nutritious and Healthy Diet, and Regular Physical Exercise. A state of inner peace and self-contentment is essential to enjoying a good physical health and over all well-being. The inner peace and self contentment is a just a state of mind.People with diabetes diseases often use complementary and alternative medicine. I diagnosed diabetes in 2010. Was at work feeling unusually tired and sleepy. I borrowed a cyclometer from a co-worker and tested at 760. Went immediately to my doctor and he gave me prescription like: Insulin ,Sulfonamides,Thiazolidinediones but Could not get the cure rather to reduce the pain but brink back the pain again. i found a woman testimony name Comfort online how Dr Akhigbe cure her HIV  and I also contacted the doctor and after I took his medication as instructed, I am now completely free from diabetes by doctor Akhigbe herbal medicine.So diabetes patients reading this testimony to contact his email     drrealakhigbe@gmail.com   or his Number   +2348142454860   He also use his herbal herbs to diseases like:SPIDER BITE, SCHIZOPHRENIA, LUPUS,EXTERNAL INFECTION, COMMON COLD, JOINT PAIN, EPILEPSY,STROKE,TUBERCULOSIS ,STOMACH DISEASE. ECZEMA, PROGENITOR, EATING DISORDER, LOWER RESPIRATORY INFECTION,  DIABETICS,HERPES,HIV/AIDS, ;ALS,  CANCER , MENINGITIS,HEPATITIS A AND B,ASTHMA, HEART DISEASE, CHRONIC DISEASE. NAUSEA VOMITING OR DIARRHEA,KIDNEY DISEASE. HEARING LOSSDr Akhigbe is a good man and he heal any body that come to him. here is email    drrealakhigbe@gmail.com    and his Number +2349010754824

    ReplyDelete
  3. Greetings my people i am  here to testify about this  great DR_ANUDE  from african i want to inform the world that the cure to HVS is out and real he have the remendy to get you cured from herpes and hiv/aids including other dieases he have help many people including me  the medicine will be in a form of a liquid after preparation you will use it for 23days and you will be free completing he also have remedy for below dieases..  whatsapp him on +2348164866838 or email him dranuge@gmail.com

    1) HERPES 

    2) HIV/AIDS 

    3) DIABETES


    4) BLOOD CANCER


    5) HPV


    6) HEPATITIS



    7) EPILEPSY


    8) ALS9) FIBROID


    10) SICKLE AND ANAEMIA... 

    whatsapp him on  +2348164866838 or you can also Email him on dranuge@gmail.com

    ReplyDelete
  4. I am here to give my testimony about chief dr OYAkRIRE who helped me in my life, i want to inform the public how i was cured from HIV simplex virus by chief dr oyakhire,i visited different hospital but they gave me list of drugs like Famvir, Zovirax, and Valtrex which is very expensive to treat the symptoms and never cured me. I was browsing through the Internet searching for remedy on HIV and i saw comment of people talking about how chief dr OYAKHIRE cured them. when i contacted him he gave me hope and send a Herbal medicine to me that i took and it seriously worked for me, am a free person now without problem, my HIV result came out negative. I pray for you chief dr OYAKHIRE am cured you can also get your self cured my friends if you really need my doctor help, you can reach him now.

    Call or What's App +2349039208180 or email droyakhire7@gmail.com

    He also specialize on the following things

    1. HPV.
    2. HERPES 1/2
    3. CANCER
    4. ALS (Lou Gehrig's disease)
    5. Hepatitis B
    6. chronic pancreatic
    7. emphysema
    8. COPD (chronic obstructive pulmonary disease)

    ReplyDelete
  5. Never give up in life they all say no cure to HSV 2 which is a big lie I have pass through many process also i never believe there is really cure to HERPES until I meet Dr.Ehiaguna the doctor that have been helping many people for many years, I come across this doctor online when I was searching for cure online I found out about this man, and to my greatest surprise this man have the herbal medicine which I have been looking for years I explain my problem to him through the email I found on someone who testify about him also, Dr.Ehiaguna write me a reply and explain how the process work so after ordering for the medicine I got it within 4 days and I took it according to the way Dr.Ehiaguna instructed, I was so happy after two week I took the medicine there was very big change in my health when I was done with the process I go for test, I found out I am negative that was the day I have the tears of joy you can also get in contact with my doctor through his email now drehiaguna@gmail.com or you can also WhatsApp him +2348073908953. And He also have herbs medicine to cured the following diseases; eczema,urethra wart,chronic problems.Herpes, Cancer, Als,Hepatitis, Diabetes, HPV,Infections,ulcer  ETC

    ReplyDelete
  6. Never give up in life they all say no cure to HSV 2 which is a big lie I have pass through many process also i never believe there is really cure to HERPES until I meet Dr.Ehiaguna the doctor that have been helping many people for many years, I come across this doctor online when I was searching for cure online I found out about this man, and to my greatest surprise this man have the herbal medicine which I have been looking for years I explain my problem to him through the email I found on someone who testify about him also, Dr.Ehiaguna write me a reply and explain how the process work so after ordering for the medicine I got it within 4 days and I took it according to the way Dr.Ehiaguna instructed, I was so happy after two week I took the medicine there was very big change in my health when I was done with the process I go for test, I found out I am negative that was the day I have the tears of joy you can also get in contact with my doctor through his email now drehiaguna@gmail.com or you can also WhatsApp him +2348073908953. And He also have herbs medicine to cured the following diseases; eczema,urethra wart,chronic problems.Herpes, Cancer, Als,Hepatitis, Diabetes, HPV,Infections,ulcer  ETC

    ReplyDelete
  7. HELLO EVERYONE.. FEW MUNINETS TO REDY THIS INFOR ON HERPES CURE 2018..
    2017 MY MOTHER WAS DIAGNOSED OF HERPES/ KNOWN AS GENITAL WARTS ,I SPENT A LOT OF MONEY ON HER MEDICATION TILL A POINT I EVEN LOST HOPE,BECAUSE MY MOTHER WAS GRADUALLY DYING AND LOST HER MEMORY TOO, I WAS SO DESPERATE TO GET MY MOTHER BACK TO NORMAL, ONE DAY MY UNCLE WHO LIVES IN LONDON UNITED KINGDOM TOLD ME ABOUT DR OLIHA ,WHO HELPED HIM GET RID OF HERPES /GENITAL WART WITH HERBAL MEDICINE AND HIS HERBAL SOAP ,I WAS SO SHOCKED WHEN HE TOLD ME ABOUT THIS ,ALTHOUGH I NEVER BELIEVE IN HERB BUT, I KEEP TO BELIEVE BECAUSE MY UNCLE CAN'T TELL ME LIES WHEN IT COMES TO HEALTH CONDITION I CONTACTED DR OLIHA VIA HIS EMAIL; OLIHA.MIRACLEMEDICINE@GMAIL.COM , YOU CAN TALK TO HIM VIA CALL OR WHATSAPP MESSENGER ON +2349038382931 , HE REPLIED AND ASK ME TO SEND MY HOME ADDRESS AND MY MOTHER'S DETAIL AND THEN I PURCHASED THE HERBAL MEDICINE,SENT ME THE HERBAL MEDICINE THROUGH COURIER SERVICE, WHEN I RECEIVED THIS HERBAL MEDICINE USED IT FOR 2 WEEKS, AND 4 DAYS OF USAGE THE WARTS FELL OFF, MY MOTHER I NOW TOTALLY CURED AND MY MOTHER IS LIVING FREE AND HAPPY AGAIN. YOU CAN TALK TO DR VIA HIS MOBILE NUMBER OR WHATS APP HIM ON +2349038382931.ALL THANKS TO DOCTOR DR OLIHA  

    ReplyDelete
  8. Hello views join my to appreciate Dr. Oseremen for the great work he did for me, that have be my happiest day in my life this true life story you should pickup a point. I have been diagnose of herpes virus for eight [8] years,I’ve lost all hope and that there is no cure and I have been taken medicine to sustain myself till I got to know about Dr. Oseremen through a friend who he cured of herpes. I contacted him and he sent me his herbal medicine which I took as he directed me to do for 21 days and after taking his herbs, I went to the hospital and I was confirmed herpes Negative after years of pains and suffering , it is indeed a miracle, Dr. Oseremenis a great man, I have heard so much about how he has help lot of people, if you have any issue you can contact him for help.via email him on. Dr.oseremenvadi@gmail.com  you can as well call his mobile number or add him on whatsapp +2349056394313

    ReplyDelete
  9. Herpes is a serious and recurring disease which can't be cured through drugs or injections by the doctors but the best way to deal with Herpes is by taking natural herbs medicine for it,  I have read about DR NOGADU the great herbalist doctor who cure me from herpes  with his powerful herbal medicine.  i contacted him to know how he can help me and he told me never to worry that he will help me with the natural herbs from God! After 2 days of contacting him, he told me that the cure has been ready and he sent it to me via UPS SPEED POST and it got to me after 3 days! i used the medicine as he instructed me (MORNING and EVENING) and i was cured! It was really like a dream but i was  so happy! you should contact him for his herbal medicine because i am a living testimony and i was cured of herpes and his medicine is legit.  I sent him what he requested and he sent me his medicine which I took for 2 good weeks and today I am out here with a negative result. When I went for the test I was so happy after going through his medication. you can reach him through his email: drnogaduherbalist@gmail.com or call/whatsapp number:+2347010627760 he will help you out.

    ReplyDelete
  10. I am here to give my testimony about Dr Anuge who helped me.. i want to inform the public how i was cured from (HERPES SIMPLEX VIRUS) by Dr Anuge, i visited different hospital but they gave me list of drugs like Famvir, Zovirax, and Valtrex which is very expensive to treat the symptoms and never cured me. I was browsing through the Internet searching for remedies on HERPES and I saw comments of people talking about how Dr anuge cured them. When I contacted him he gave me hope and sent Herbal medicine to me that I took for just 2 weeks and it seriously worked for me, my HERPES result came out negative. I am so happy as I am sharing this testimony. My advice to you all who thinks that there is no cure for herpes that is Not true just contact him and get cure from Dr Anuge healing herbal cure of all kinds of sickness you may have like
    (1) CANCER,
    (2) DIABETES,
    (3) HIV AIDS,
    (4) URINARY TRACT INFECTION,
    (5) CANCER,
    (6) IMPOTENCE,
    (7) BARENESS/INFERTILITY
    (8) DIARRHEA
    (9) ASTHMA
    (10)SIMPLEX HERPES AND GENITAL
    (11)COLD SORE
    and mare that are not mentioned here He also cured my friend from cervical cancer. so contact him through his Email address : dranuge@gmail.com or whatsapp him on +234816466838 

    ReplyDelete
  11. *Herpes is a serious and recurring disease which can't be cured through drugs or injections by the American doctors but the best way to deal with Herpes is by taking natural herbs medicine for it and is only few American doctors that know about this herbal medicine from Dr odion.. I have read about Dr odion the great herbalist doctor from African who can cure Herpeewith his powerful herbal medicine. for the people suffering from the following diseases Hiv, Herpes, Cancer, Als,Herpatitis, Diabetes, Hpv,Infections ETC should contact him for his herbal medicine because i am a living testimony and i was cured of Herpes. Although, i sent him what he requested and he sent me his medicine which i took for two weeks and today when i went for test i was tested Herpes negative and he can also cure herpes etc you can reach him through his WhatsApp number:+2349019421176 he will help you out or email drodionherbalhome12@gmial.com*

    ReplyDelete
  12. FINALLY FREE FROM HERPES VIRUS. what a miracle i never believe there is cure because my doctor tested me herpes positive and she told me there is no cure, i’m very happy today that i’m having a free life without this herpes virus, i can remember some months ago when i was crying all through the night and day that i can’t get cured from this herpes, i found this herbal man called Dr Adigba on internet when i was doing research on cure for shingle i contacted him to found out if i can get help from this herpes virus, i was so surprise when he told me that he have the herbs cure to it and he sent me the herbal in less down 5 days i was so happy when i get someone giving me hope that he can cured me i took the herbal for just 2 weeks, when i went for test after taking the herbal i found out that i am cured i was so happy and surprise, i want to use this opportunity to inform you that there is cured to herpes virus you can also contact him for his help as soon as possible so that you can get rid of this herpes once and for all you can reach him through this email: dradigba@gmail.com or whatsApp him on +2348077875210 You can also contact him on any disease and virus in this he all have the herbal cure to it. 1 HIV/AIDS 2 HERPES 3 CANCER 4 ALS 5 HEPATITIS 6 DIABETES 7 LOVE SPELL 8 INFECTIONS 9 HIGN BLOOD PRESSURE,..... THANKS TO DR SUNNYNA FOE THE GOOD WORK IN LIFE YOU BLESS.....    

    ReplyDelete
  13. I want to share this great testimony to the world on how Dr VOODOO cure me from HSV1&2 with his herbs, I was nervous when i first contact him about the cure for HSV but i decided to give him a try because i was desperate to get cured and be free from HSV. Dr VOODOO prepared the remedy and sent it to me through UPS,which I use just the way Dr VOODOO instructed me and thank God today I am a beneficiary to this cure and I went back to the hospital after 7 days of taking the herbs and I tested HSV1&2 Negative. So I will tell you all who are looking for a cure to his/her HSV1&2 that Dr VOODOO took research before he could finally get the solution to it and a lot of people are benefiting from him right now. He also cured my friend from HPV. Dr VOODOO heals with natural herbs. Please I urge you to contact him now through his email address: voodoospelltemple66@gmail.com or call and WhatsApp him on +2348140120719. He is capable of curing HIV/AIDS, HERPES, HPV, HSV1&2, CANCER of all kinds, DIABETES and so many other infections.

    ReplyDelete
  14. I’m recommending Dr Godday to everyone who have herpes virus to get the cure from him. I was diagnose of genital herpes in 2015 and i have been searching and asking questions to see if i could get something to cure the disease because i did not believe what the doctors say that no cure is found yet. I came across a comment on Youtube and the person testify how she was cured from herpes and hpv after using Dr Godday herbal medicine. I quickly contact Dr email and explain my problem to him and he prepare the herbs and send it to me through courier and gave me instructions on how to use it and tell me to go for checkup after usage which i did after two weeks of taken the herbal medicine and my result was NEGATIVE. I waited another month and retested the result was still NEGATIVE and my doctor told me that am completely free from herpes. Am so happy and grateful to Dr Godday for what he has done for me and i will continue to share this for people out there to know that there is cure for herpes. You can contact Dr Godday on email and WhatsApp to get the cure from him. Email:goddayspiritualhome@gmail.com Or Call/What’s-app +1{919}4956404

    ReplyDelete
  15. My health was horrible before I decided to try the Protocol Of taking Dr. Omola pure herbal mixture. I felt there was no hope for my health and I was to try the Protocol, thinking it wouldn’t work because I have visited so many hospital but same result. However, I was convinced by a Instagram friend to try the herbal medicine because I wanted to get rid of Herpes virus. The herbal mixture that was given to me was really quick and easy to take, within 2 week i was fully cured from Herpes. The herbal medicine really work and I will like to share this great doctor contact with you all email him dr.omolaherbalhome@gmail.com or WhatsApp +2348118116254 you won't regret it, i promise.

    ReplyDelete
  16. My health was horrible before I decided to try the Protocol Of taking Dr. Omola pure herbal mixture. I felt there was no hope for my health and I was to try the Protocol, thinking it wouldn’t work because I have visited so many hospital but same result. However, I was convinced by a Instagram friend to try the herbal medicine because I wanted to get rid of Herpes virus. The herbal mixture that was given to me was really quick and easy to take, within 2 week I was fully cured from Herpes. The herbal medicine really work and I will like to share this great doctor contact with you all email him dr.omolaherbalhome@gmail.com or WhatsApp +2348118116254 you won't regret it, I promise.

    ReplyDelete
  17. MY HIV HEALING TESTIMONY

    My mouth is short of words, i am so happy because Dr voodoo has healed me
    from HIV which i have been suffering from the past 5years now, i have
    spend a lot when getting drugs from the hospital to keep me healthy, i have
    tried all means in life to always i can become HIV negative one day, but
    there was no answer until i found Dr voodoo the parish of African who
    provide me some healing herbs that i uses , now i am glad telling everyone
    that i am now HIV Negative, i am very happy, thank you Dr voodoo for
    helping my life comes back newly without any form of crisis, may the good
    lord that i serve blessed you Dr voodoo and equip you to the higher grade
    for healing my life. i am so amazed. so i will announced to everyone in
    this whole world that is HIV positive to please follow my advice and get
    healed on time, because we all knows that HIV disease is a deadly
    type,contact Dr voodoo for your HIV healing herbs today at:
    voodoospelltemple66@gmail.com He will be always happy to assist you
    online and ensure you get healed on time, contact Dr voodoo today for
    your healing hearbs immediately, you can also
    add him on whatsApp +2348140120719 thank you sir.

    ReplyDelete